São Paulo vs Atlético Nacional Prediction, Betting Tips, Lineups & Odds | 19 Aug 2025

Copa Libertadores Betting Preview: São Paulo vs Atlético Nacional

Brazilian Série A outfit São Paulo host Colombian Categoría Primera A side Atlético Nacional in the second leg of this Copa Libertadores round of 16 tie at Estádio do Morumbi, with kick-off set for 08:30 on Wednesday 20 August. Our betting preview features expert predictions, betting tips, the latest odds, H2H stats, team news and confirmed lineups.

We’re Backing São Paulo To Claim Victory

São Paulo look like a standout bet when it comes to the Full-Time Result market. There are odds of 1.78 that the home team overcome Atlético Nacional and we’re confident that this is a value play.

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Goalless Draw in First Leg

São Paulo played Sport Recife on their travels in their last game. It was a 2-2 Série A draw. Tricolor Paulista had seven shots on target and enjoyed 67% possession, while Lucas Moura and Maik Gomes each scored one goal.

Atlético Nacional drew their previous game which was at home in the Primera A. The action ended 2-2 against Fortaleza.

Head-to-Head Statistics

The first leg ended 0-0 as Nacional and São Paulo cancelled each other out. The Colombians enjoyed 55% possession and managed the game’s only effort on target.

Copa Libertadores		G	W	D	L	GF	GA	GD	GD	P
1	São Paulo	6	4	2	0	10	4	6	10:4	14
2	Atlético Nacional	6	3	0	3	7	6	1	7:6	9

View Full Table

Confirmed Lineups

São Paulo confirmed lineup (3-5-2): Rafael (GK), Nahuel Ferraresi, Alan Franco, Sabino, Cedric Soares, Damian Bobadilla, Marcos Antonio, Rodriguinho, Enzo Hernan Diaz, Luciano Neves, Andre.

Atlético Nacional confirmed lineup (4-2-3-1): David Ospina (GK), Felipe Roman, Juan Jose Arias, William Tesillo, Camilo Candido, Juan Zapata, Jorman Campuzano, Marino Hinestroza, Edwin Cardona, Marlos Moreno, Alfredo Morelos.

São Paulo vs Atlético Nacional Prediction & Betting Tips

Our São Paulo vs Atlético Nacional betting tips provide expert coverage of all major angles, including our main match prediction, top player prop picks, correct score recommendation and best bet builder insights.

Match Prediction

It’s great to get attractive odds of 1.78 for a home win in this Copa Libertadores encounter. We think that São Paulo will have the upper hand and this could be the best way of getting value.

The team news that filters through can have a knock-on effect as far as the Copa Libertadores odds are concerned. We use this information along with the form guide, while the latest stats are also taken into consideration when making football predictions.

Key São Paulo vs Atlético Nacional Copa Libertadores & league stats:

• São Paulo have won 4 of their last 5 games at home.
• São Paulo have won 6 of their last 10 games at home.
• São Paulo have won 3 consecutive games at home.

São Paulo to Win Probability

Based on the odds from the best betting apps, our pick carries a 56.2% chance of winning. However, our experts have this number between 60-65% based on their in-depth research. This is why we can recommend this wager.

Those looking for tastier odds about a win for São Paulo can take a look at the Match Result & Total market. You can combine your match winner pick with an Under / Over goals prediction for more juice.

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Our Match Prediction

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Correct Score Prediction

São Paulo 2 - 0 Nacional

We’ve picked out a correct score of 2-0 being landed by São Paulo. You can secure odds of 7.00 and this provides an alternative way to place a wager.

Player Prop Picks

São Paulo vs Atlético Nacional Odds

The odds are updated on a frequent basis. You might therefore find that they are different to the ones listed for the above betting predictions.

Latest Full-Time Odds Suggest São Paulo Victory

São Paulo are forecasted to have a 53% chance of triumphing in this Copa Libertadores encounter according to the bookmakers. It leads to their latest betting odds being 1.87. At 4.75, Atlético Nacional are regarded as having a lower probability of winning.

São Paulo are 1.87 when it comes to the Asian Handicap -0.5 which is the same as backing them on the 1x2 market. If you instead want to bet on Nacional +0.5 at 1.93, you also get paid out if it’s a draw.

For the Total Goals market, Under 2.5 is the shortest price for this interesting contest. The Both Teams to Score No bet is 1.56 and it’s ideal if you think at least one side will not score during the ninety minutes.

The top football betting sites are on hand to provide lots of choice to bettors. It’s now the case that you can select from hundreds of markets for all of the Copa Libertadores games.

Luciano da Rocha Heads First Goalscorer Market

Favourite Luciano da Rocha is 5.50 to be the First Goalscorer, while similar odds apply when it comes to him scoring the last goal.

Latest Copa Libertadores and domestic league stats. Full Time Result, Goals, Corners and Possession.

São Paulo Stats

Atlético Nacional Stats

Full-Time Result

• 5 wins, 3 defeats and 2 draws in the previous 10 matches
• 5 wins, 2 defeats and 3 draws in the previous 10 home matches

Full-Time Result

• 5 wins, 2 defeats and 3 draws in the previous 10 matches
• 3 wins, 3 defeats and 4 draws in the previous 10 away matches

Goals

• An average of 1.60 goals scored and 1.30 conceded in the previous 10 matches
• An average of 1.30 goals scored and 0.90 conceded in the previous 10 home matches
• An average of 2.90 goals per game in the previous 10 matches
• An average of 2.20 goals per game in the previous 10 home matches
• BTTS Yes in 6 of the previous 10 matches
• BTTS Yes in 5 of the previous 10 home matches
• Over 2.5 Goals in 6 of the previous 10 matches
• Over 2.5 Goals in 4 of the previous 10 home matches

Goals

• An average of 1.70 goals scored and 1.00 conceded in the previous 10 matches
• An average of 1.00 goals scored and 0.90 conceded in the previous 10 away matches
• An average of 2.70 goals per game in the previous 10 matches
• An average of 1.90 goals per game in the previous 10 away matches
• BTTS Yes in 7 of the previous 10 matches
• BTTS Yes in 6 of the previous 10 away matches
• Over 2.5 Goals in 7 of the previous 10 matches
• Over 2.5 Goals in 5 of the previous 10 away matches

São Paulo vs Atlético Nacional Lineups & Team News

Be smart with your bets — check the São Paulo vs Nacional team news beforehand. We’ll provide the predicted and confirmed lineups for the Copa Libertadores along with up-to-date injury news.