South Carolina vs Missouri Prediction, Picks & Odds | 20 Sep 2025

College Football Betting Preview: South Carolina vs Missouri

South Carolina face Missouri in this NCAAF Week 4 matchup at Faurot Field, with kickoff scheduled for 07:00 on Sunday 21 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Mizzou Look the Value Bet

Missouri are available at odds of 1.91 when it comes to backing them against the spread. The -9.5 line could be covered with ease in their clash against against South Carolina and this looks like a value bet.

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Mizzou Have Won 5 of Previous 6 H2H Matchups

South Carolina Gamecocks were defeated in their previous game. They were beaten at home to Vanderbilt Commodores by a 31-7 scoreline at Williams-Brice Stadium.

Missouri Tigers won their last game 52-10, making it three victories on the bounce. This was a home win at Faurot Field against Louisiana Ragin Cajuns.

Head-to-Head Statistics

The last matchup between South Carolina and Missouri saw the former win. It was a 34-30 scoreline at Williams-Brice Stadium. Missouri have won five of the previous 6 H2H meetings.

Quarterbacks

LaNorris Sellers

Beau Pribula

South Carolina vs Missouri Prediction & Picks

Get the full betting picture for South Carolina vs Missouri, including our expert match prediction, likely scoreline, must-watch player props and a tailored bet builder ready to use.

Game Prediction

Missouri should secure a comfortable win and a bet on the spread could be the best way forward in this college football battle. Back this selection off -9.5 to cover the line at 1.91.

Tracking injury updates is a big part of our CFB analysis and team news plays a major role in shaping our picks. We combine this with recent form and the most important stats to get a complete picture.

Key South Carolina vs Missouri stats:

• The -9.5 line has been covered by Missouri in 3 consecutive games.

Mizzou -9.5 Probability

Looking at the latest betting odds, our pick has a 52.4% chance of winning. After careful examination, our cappers have this probability somewhere between 55-60%. This is why we regard this as a value bet.

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Best Bet

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Player Prop Picks

Correct Score Prediction

South Carolina 17 - 34 Missouri

There’s a massive payout on the cards should you correctly predict the correct score. We’re siding with the Tigers to enjoy a 34-17 victory which will hopefully go close.

South Carolina vs Missouri Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Have Mizzou as Heavy Favorites

Missouri have the shortest price to win this college game, with the sportsbooks giving them a 79% probability due to their 1.27 Moneyline betting odds. For those wanting to oppose the market leader, you can get 3.85 about South Carolina.

The spread currently stands at 9.5 and the total points line is 48.5. Football fans love the chance to get an alternative angle by going for a Total wager. There’s the chance to back Under 48.5 at 1.91.

There are a wide range of game lines and team props when it comes to most college football matchups and we recommend visiting the best betting apps to find the wager that matches your view on the game.

Ahmad Hardy Favorite to Be First TD Scorer

There is 1.53 available that Ahmad Hardy scores a touchdown anytime. If you’re interested in the favorite to score the first TD, then you are able to secure 5.00.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Micro Betting

Micro betting provides a rollercoaster ride for college football bettors. It can be great to enjoy the live lines, with the opportunity to wager on the Next Scoring Play. Watch the live action before deciding which way to go.

Can Missouri Continue Strong Home Form?

Missouri have ten wins and zero loss in the last 10 home games, scoring 38.00 points per contest and conceding 15.60.

South Carolina have four wins and six losses in the last 10 games on the road, averaging 21.60 points scored and 21.30 points allowed.

Missouri beat South Carolina 34-12 when the teams last met at Faurot Field. Looking at the past 3 head-to-head meetings at Faurot Field, Missouri have taken every win.

Last 10 Games		W-L	P	PF	PA	O48.5	U48.5
Missouri Home Stats		10-0	53.60	38.00	15.60	7	3
South Carolina Away Stats		4-6	42.90	21.60	21.30	2	8

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O48.5 = Games Over 48.5 Points
• U48.5 = Games Under 48.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

South Carolina Gamecocks Stats

Missouri Tigers Stats

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 8 wins and 2 defeats in the last 10 games
• 10 wins and 0 defeats in the last 10 home games

Point Spread

• +9.5 Betting Line: Have covered the spread in 9 of the last 10 games
• +9.5 Betting Line on the Road: Have covered the spread in 6 of the last 10 games on the road

Point Spread

• -9.5 Betting Line: Have covered the spread in 4 of the last 10 games
• -9.5 Betting Line at Home: Have covered the spread in 4 of the last 10 home games

Total Points

• Game Totals: An average of 46.50 pts in the previous 10 games
• Game Totals on the Road: An average of 42.90 pts in the previous 10 games on the road
• Over 48.5: Covered in 3 of the previous 10 games
• Over 48.5 on the Road: Covered in 2 of the previous 10 games on the road
• Team Totals: Have scored an average of 30.00 pts and allowed 16.50 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.60 pts and allowed 21.30 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 55.00 pts in the previous 10 games
• Game Totals at Home: An average of 53.60 pts in the previous 10 home games
• Over 48.5: Covered in 8 of the previous 10 games
• Over 48.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 33.00 pts and allowed 22.00 pts in the last 10 games
• Team Totals at Home: Have scored an average of 35.60 pts and allowed 18.00 pts in the last 10 home games

NCAAF Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Southeastern	W	L	PF	PA	N. Pts	Home	Away	Strk
Auburn	3	0	111	42	69	2-0	1-0	3W
Georgia	3	0	117	54	63	2-0	1-0	3W
LSU	3	0	60	27	33	2-0	1-0	3W
Mississippi State	3	0	121	37	84	2-0	1-0	3W
Missouri	3	0	155	47	108	3-0	0-0	3W
Oklahoma	3	0	101	19	82	2-0	1-0	3W
Ole Miss	3	0	134	65	69	2-0	1-0	3W
Texas A&M	3	0	127	86	41	2-0	1-0	3W
Vanderbilt	3	0	120	30	90	1-0	2-0	3W
Alabama	2	1	128	45	83	2-0	0-1	2W
Kentucky	2	1	95	69	26	2-1	0-0	1W
South Carolina	2	1	69	52	17	2-1	0-0	1L
Tennessee	2	1	158	87	71	2-1	0-0	1L
Texas	2	1	72	31	41	2-0	0-1	2W
Arkansas	2	2	174	94	80	2-0	0-2	2L
Florida	1	2	81	38	43	1-1	0-1	2L