Cardinals vs 49ers Prediction, Picks & Odds | 21 Sep 2025

NFL Betting Preview: Cardinals vs Niners

The Arizona Cardinals face the San Francisco 49ers in this NFL Week 3 matchup at Levi's Stadium, with kickoff scheduled for 04:25 on Monday 22 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Cardinals Primed to Win This Matchup

The Cardinals should be able to outscore the Niners and our prediction is to side with them on the Moneyline. There is a tempting 2.10 should you wish to follow suit.

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Teams’ Last Matchup Saw 47-24 Cardinals Win

Arizona Cardinals claimed a home victory in their previous game. A 27-22 triumph against Carolina Panthers at State Farm Stadium made it back-to-back wins. The Cardinals put up 293 yards, including 211 passing and 82 rushing yards. The offense managed 16 first downs and reached the end zone 3 times, 1 via the pass and 1 on the ground.

San Francisco 49ers have triumphed in back-to-back games. The latest of these was on the road where New Orleans Saints were beaten 26-21 at Caesars Superdome. The 49ers totaled 344 yards, with 267 through the air and 77 on the ground. They scored 3 touchdowns and picked up 23 first downs.

Head-to-Head Statistics

The Cardinals have beaten the Niners in the last two matchups. A 24-23 victory at Levi's Stadium was followed by a 47-24 win at State Farm Stadium. Both teams have won five games when it comes to the previous 10 H2H meetings.

Quarterbacks

Kyler Murray

Mac Jones

Cardinals vs 49ers Prediction & Picks

The Cardinals vs 49ers betting tips feature sharp analysis across major markets, including a key match prediction, player prop bets, correct score guidance and a ready-made bet builder.

Game Prediction

We are eager to back the Cardinals to win this NFL matchup and that leads us to the Moneyline for our pick. It’s difficult to turn down the 2.10 that they claim the win.

The NFL handicappers at jeetwin24.com start by analyzing recent form and staying on top of injury news before making any predictions. From there, we interpret the story the stats are telling to help shape our picks.

Key Cardinals vs 49ers stats:

• Cardinals have won 3 consecutive games.
• 49ers have lost 7 of their last 10 games.
• 49ers have lost 12 of their last 20 games.
• 49ers have lost their last 2 games at home.
• 49ers have lost their last 2 games against Cardinals.

Cardinals Moneyline Probability

If you go by the top betting sites, there’s a 47.6% likelihood of our pick landing a return. In the opinion of our analysts, there’s actually a probability of success between 50-55%. It’s why we think it’s worth placing this bet.

If you’re looking to squeeze more juice from the odds, consider the Cardinals on the spread. Those expecting this franchise to exceed expectations can bet them to cover the line.

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Best Bet

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Player Prop Picks

Correct Score Prediction

Cardinals 31 - 23 49ers

For those looking to get more bang for their buck, consider a correct score bet on the Cardinals. Backing them to win 31-23 means you can land a potential monster return.

Cardinals vs 49ers Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Latest Odds Suggest a Close Contest

When you consider the latest Moneyline odds, you can find San Francisco 49ers at 1.82 whereas Arizona Cardinals are 2.04. This means the leading sportsbooks give the visiting team a 49% chance of success.

The spread currently stands at 1.5 and the total points line is 44.5. Having a wager on the Totals is one of the most popular NFL bets. There’s the chance to back Under 44.5 at 1.91.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Christian McCaffrey Favorite to Be First Touchdown Scorer

The First Touchdown Scorer favorite is Christian McCaffrey at 4.80. Similar odds can be found if you’re interested in this player to register the final TD.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Micro Betting

An increasing number of bettors are now enjoying micro betting on the NFL and it’s something which is available on an in-game basis. Wait for the action to start and then wager on something specific to happen.

Niners Hold Five Wins in Previous Ten at Home

The Niners have a 5-5 record in their last 10 home games, scoring 26.20 points per contest and conceding 22.40.

The Cardinals own a 4-6 mark in their past 10 road games, averaging 21.50 points scored and 25.00 points allowed.

The last time the teams met at Levi's Stadium, the Cardinals defeated the Niners 24-23. The last 6 head-to-head matchups at Levi's Stadium have been split, with each team winning three times.

Last 10 Games		W-L	P	PF	PA	O44.5	U44.5
49ers Home Stats		5-5	48.60	26.20	22.40	7	3
Cardinals Away Stats		4-6	46.50	21.50	25.00	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O44.5 = Games Over 44.5 Points
• U44.5 = Games Under 44.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

Arizona Cardinals Stats

San Francisco 49ers Stats

Moneyline

• 5 wins and 5 defeats in the last 10 games
• 4 wins and 6 defeats in the last 10 games on the road

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 5 wins and 5 defeats in the last 10 home games

Point Spread

• +2.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +2.5 Betting Line on the Road: Have covered the spread in 5 of the last 10 games on the road

Point Spread

• -2.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -2.5 Betting Line at Home: Have covered the spread in 5 of the last 10 home games

Total Points

• Game Totals: An average of 44.00 pts in the previous 10 games
• Game Totals on the Road: An average of 46.50 pts in the previous 10 games on the road
• Over 44.5: Covered in 6 of the previous 10 games
• Over 44.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 24.00 pts and allowed 20.00 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.50 pts and allowed 25.00 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 46.70 pts in the previous 10 games
• Game Totals at Home: An average of 48.60 pts in the previous 10 home games
• Over 44.5: Covered in 7 of the previous 10 games
• Over 44.5 at Home: Covered in 7 of the previous 10 home games
• Team Totals: Have scored an average of 19.90 pts and allowed 26.80 pts in the last 10 games
• Team Totals at Home: Have scored an average of 26.20 pts and allowed 22.40 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 359.80 Yds. Allowed 318.50 Yds
• Rushing Yards: Gained 131.50 Yds. Allowed 105.30 Yds
• Passing Yards: Gained 228.30 Yds. Allowed 213.20 Yds
• Total Touchdowns: Scored 2.50 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.30 TD
• Total 1st Downs: Picked up 21.70. Allowed 19.30
• Total Turnovers: Committed 1.00. Committed by opponents 0.90
• Total Penalties: Committed 7.00. Committed by opponents 7.30
• Penalty Yards: Lost 58.80 Yds. Gained 60.60 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 341.30 Yds. Allowed 319.20 Yds
• Rushing Yards: Gained 101.20 Yds. Allowed 136.90 Yds
• Passing Yards: Gained 240.10 Yds. Allowed 182.30 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.60 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 20.20. Allowed 19.50
• Total Turnovers: Committed 1.90. Committed by opponents 0.50
• Total Penalties: Committed 7.30. Committed by opponents 4.40
• Penalty Yards: Lost 50.30 Yds. Gained 34.70 Yds

Last 10 Games on the Road

• Total Yards: Gained 352.40 Yds. Allowed 329.50 Yds
• Rushing Yards: Gained 133.60 Yds. Allowed 119.80 Yds
• Passing Yards: Gained 218.80 Yds. Allowed 209.70 Yds
• Total Touchdowns: Scored 2.00 TD. Allowed 2.80 TD
• Rushing Touchdowns: Scored 0.60 TD. Allowed 0.90 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 21.20. Allowed 20.00
• Total Turnovers: Committed 1.30. Committed by opponents 0.80
• Total Penalties: Committed 7.00. Committed by opponents 6.10
• Penalty Yards: Lost 53.50 Yds. Gained 49.60 Yds

Last 10 Home Games

• Total Yards: Gained 380.30 Yds. Allowed 309.50 Yds
• Rushing Yards: Gained 136.00 Yds. Allowed 118.80 Yds
• Passing Yards: Gained 244.30 Yds. Allowed 190.70 Yds
• Total Touchdowns: Scored 2.80 TD. Allowed 2.60 TD
• Rushing Touchdowns: Scored 1.60 TD. Allowed 1.40 TD
• Passing Touchdowns: Scored 1.00 TD. Allowed 1.20 TD
• Total 1st Downs: Picked up 20.90. Allowed 18.30
• Total Turnovers: Committed 1.50. Committed by opponents 1.30
• Total Penalties: Committed 5.60. Committed by opponents 3.50
• Penalty Yards: Lost 37.70 Yds. Gained 27.50 Yds

Team News

NFL Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Division Conference League

AFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	2	0	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Dolphins	0	3	0	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L
Jets	0	3	0	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L

AFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	1	0	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Steelers	2	1	0	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Browns	1	2	0	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W

AFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	3	0	0	1.000	103	56	47	2-0-0	1-0-0	1-0-0	3-0-0	3-0-0	3W
Jaguars	2	1	0	0.667	70	51	19	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Texans	0	3	0	0.000	38	51	-13	0-1-0	0-2-0	0-1-0	0-1-0	0-3-0	3L
Titans	0	3	0	0.000	51	94	-43	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L

AFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	3	0	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Chiefs	1	2	0	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W
Raiders	1	2	0	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Broncos	1	2	0	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L

NFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Commanders	2	1	0	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Giants	0	3	0	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	1	0	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Vikings	2	1	0	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Bears	1	2	0	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W

NFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	3	0	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Falcons	1	2	0	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Panthers	1	2	0	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Saints	0	3	0	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L

NFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	3	0	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	1	0	0.667	62	51	11	1-0-0	1-1-0	0-1-0	2-1-0	2-1-0	1L
Seahawks	2	1	0	0.667	88	47	41	1-1-0	1-0-0	0-1-0	1-1-0	2-1-0	2W
Rams	2	1	0	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L

AFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Chargers	3	0	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Bengals	2	1	0	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Colts	3	0	0	1.000	103	56	47	2-0-0	1-0-0	1-0-0	3-0-0	3-0-0	3W
Raiders	1	2	0	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Patriots	1	2	0	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Steelers	2	1	0	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Broncos	1	2	0	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L
Jaguars	2	1	0	0.667	70	51	19	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Titans	0	3	0	0.000	51	94	-43	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Chiefs	1	2	0	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W
Jets	0	3	0	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Browns	1	2	0	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W
Texans	0	3	0	0.000	38	51	-13	0-1-0	0-2-0	0-1-0	0-1-0	0-3-0	3L
Dolphins	0	3	0	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

NFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Buccaneers	3	0	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Packers	2	1	0	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
49ers	3	0	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	1	0	0.667	62	51	11	1-0-0	1-1-0	0-1-0	2-1-0	2-1-0	1L
Rams	2	1	0	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L
Falcons	1	2	0	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Seahawks	2	1	0	0.667	88	47	41	1-1-0	1-0-0	0-1-0	1-1-0	2-1-0	2W
Commanders	2	1	0	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Vikings	2	1	0	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Panthers	1	2	0	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Bears	1	2	0	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W
Saints	0	3	0	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L
Giants	0	3	0	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFL Team	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Colts	3	0	0	1.000	103	56	47	2-0-0	1-0-0	1-0-0	3-0-0	3-0-0	3W
Chargers	3	0	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Eagles	3	0	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
49ers	3	0	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Buccaneers	3	0	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Cardinals	2	1	0	0.667	62	51	11	1-0-0	1-1-0	0-1-0	2-1-0	2-1-0	1L
Bengals	2	1	0	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Packers	2	1	0	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Jaguars	2	1	0	0.667	70	51	19	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Rams	2	1	0	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L
Vikings	2	1	0	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Steelers	2	1	0	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Seahawks	2	1	0	0.667	88	47	41	1-1-0	1-0-0	0-1-0	1-1-0	2-1-0	2W
Commanders	2	1	0	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Falcons	1	2	0	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Panthers	1	2	0	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Bears	1	2	0	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W
Browns	1	2	0	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W
Cowboys	1	2	0	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Broncos	1	2	0	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L
Chiefs	1	2	0	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W
Raiders	1	2	0	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Patriots	1	2	0	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Texans	0	3	0	0.000	38	51	-13	0-1-0	0-2-0	0-1-0	0-1-0	0-3-0	3L
Dolphins	0	3	0	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L
Saints	0	3	0	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L
Giants	0	3	0	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L
Jets	0	3	0	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Titans	0	3	0	0.000	51	94	-43	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L